Error Code 501 occurs during the installation or update of Creative Cloud apps when the installer is unable to modify a required file because it is currently in use by another application or background process Adobe Help Center Quick Fix (Task Manager/Activity Monitor)
: Using an older version of the Creative Cloud Desktop app can sometimes lead to compatibility issues that manifest as a 501 error. Effective Resolution Strategies adobe error code 501
If a simple retry doesn't work, ensure all potential conflicts are cleared: Search for background apps Error Code 501 occurs during the installation or
restart or a temporary disablement of security software. Consistent but annoying; make sure your users aren't running multiple Adobe processes during an update." Adobe Help Center For the Technical Fix-It Guide Request: Creative Cloud App requests the installer package
Here is a nuance that stumps even senior sysadmins: Adobe Error 501 is exquisitely sensitive to system clock drift.
Background applications often interfere with Adobe’s signature checks.
Uninstall (using Adobe Creative Cloud uninstaller) and reinstall the problem application.