It sounds like you're encountering a known error with Resident Evil 5 (the original Games for Windows Live version, or possibly one of the older releases) where the game fails to load an .arc file from the nativePC folder — specifically one related to resource archives (e.g., arc 3 22 or similar indexing).
Safe, ordered troubleshooting and fixes Follow these steps in order. Stop when the problem is resolved. It sounds like you're encountering a known error
nativePC\Image\Archive\mods\character\sheva\costumes\dlc\gold\highres\arc 3 22
Reacquire the ARC file
Set Resolution= to your native screen size (e.g., 1920x1080). Save and restart the game. Address "Arc" Folder Permissions Reacquire the ARC file Set Resolution= to your