Wilms - Tumor Ppt New
This report outlines the essential components for a comprehensive presentation on Wilms Tumor (Nephroblastoma), incorporating the latest 2025–2026 clinical guidelines and research updates. 1. Epidemiology and Clinical Presentation
is ideal for explaining the blastemal/epithelial/stromal triad wilms tumor ppt new
: Girls are slightly more affected than boys. It is most common in Black children and least common in East Asian children. Rule of 10s This report outlines the essential components for a
Slide-by-Slide Outline of the New PPT
- Slide 3-4: Epidemiology & Etiology – Age peak (2-5 years), incidence, racial predilection, and genetic syndromes.
- Slide 5-7: Pathology – Classic triphasic histology (blastemal, stromal, epithelial components), anaplasia (favorable vs. unfavorable histology), and molecular markers.
- Slide 8-10: Clinical Presentation – Common signs: asymptomatic abdominal mass, hematuria, hypertension, and fever. Paraneoplastic syndromes.
- Slide 11-13: Diagnostic Workup – Imaging (Ultrasound first, then CT chest/abdomen), lab findings (Nephroblastomatosis), and staging (Stage I-V).
- Slide 14-16: Treatment Protocols (New Emphasis) – A side-by-side comparison table of COG (upfront surgery) vs. SIOP (pre-op chemotherapy). Discussion of nephron-sparing surgery for bilateral disease.
- Slide 17-19: Risk-Based Therapy – Detailed algorithm: Low-risk (Stage I favorable histology → surgery + 2 drugs) vs. High-risk (Stage IV anaplastic → surgery + 3 drugs + radiation).
- Slide 20-21: Novel & Emerging Therapies – Role of targeted therapy (e.g., BET inhibitors, IGF-1R inhibitors) and reduced radiation fields in current trials (e.g., AREN1721).
- Slide 22-23: Prognosis & Outcomes – Excellent survival (>90% for localized disease), poor prognostic factors (diffuse anaplasia, stage IV, relapse <6 months).
- Slide 24-25: Late Effects & Survivorship – Cardiac toxicity (doxorubicin), secondary malignancies, renal insufficiency, and fertility preservation.
- Slide 26-27: Case Studies – Two interactive cases: (1) Unilateral favorable histology, (2) Bilateral Wilms Tumor with syndromic features.
- Slide 28-30: Summary & Key Takeaways – One-page algorithm, top 10 pearls, and a reference list with 2024-2025 COG/SIOP updates.